Brain & Spine Injury Models

Preclinical Models of Spinal Cord Injury

A cure for traumatic spinal cord injury (SCI) remains elusive. Numerous promising therapies have failed in human clinical trials thereby underscoring the need for extensive preclinical testing of pharmacotherapies prior to the initiation of human trials. PsychoGenics utilizes the Infinite Horizon SCI model to screen the efficacy of novel therapies for SCI.

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Preclinical Models of Traumatic Brain Injury

Traumatic brain injury (TBI) has been called a silent epidemic. The United States Centers for Disease Control and Prevention reports that over 2.5 million TBIs occurred in the United States in 2010 alone. Pharmacotherapies targeted at mitigating early post - traumatic secondary degenerative pathology such as inflammation, oxidative stress and excitotoxicity, as well as therapies to promote brain plasticity in order to restore function continue to require preclinical testing.

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